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Found 32 Enz. Inhib. hit(s) with all data for entry = 50005044
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50487717((+)-Catechin 3-Gallate | CATECHIN GALLATE | CHEBI:...)
Affinity DataKi:  230nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
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TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50236531((-)-gallocatechin gallate | (2R,3S)-5,7-dihydroxy-...)
Affinity DataKi:  235nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
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TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50487718(THEAFLAVANIN)
Affinity DataKi:  286nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataKi:  335nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50153015((-)-Epicatechin-3-gallate | (-)-epicatechin 3-O-ga...)
Affinity DataKi:  400nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50487716(Theaflavin)
Affinity DataKi:  690nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
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TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50135165((+)-gallocatechin | (2R,3S)-2-(3,4,5-Trihydroxy-ph...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM23417(α-CA inhibitor, 4 | (-)-Epicatechin | (2R,3R)...)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50187665((-)-epigallocatechin | CHEMBL47386)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM50479045(CHEBI:23053 | Catechin | Epica-techin)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of NLWAAQRYGRELRRMSD-K(FITC)-FVD from Bcl-2 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
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TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Affinity DataIC50:  30nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticleDrugBank

TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM50280450(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)
Affinity DataIC50:  30nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  390nMAssay Description:Inhibition of Homo sapiens (human) DNA topoisomerase 2More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  700nMAssay Description:Inhibition of GST-fused CDK2/cyclin E (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATPMore data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  700nMAssay Description:Inhibition of GST-fused CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 cells after 10 min in presence of [gamma-32PP]ATPMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7457(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  850nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7458(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  3.75E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  4.75E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008923((S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-...)
Affinity DataIC50:  4.95E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  5.25E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) VACO 241 cellsMore data for this Ligand-Target Pair
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  5.55E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) HCT116 cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7461(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)
Affinity DataIC50:  9.65E+3nMAssay Description:Inhibition of DNA topoisomerase 1 in Homo sapiens (human) SW480 cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7462(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))TBA
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  3.73E+4nMAssay Description:Inhibition of DNA topoisomerase 2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM15236(3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...)
Affinity DataIC50:  3.73E+4nMAssay Description:Inhibition of DNA topoisomerase 1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of Homo sapiens (human) cyclin-dependent kinase 6More data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 2(Saccharomyces cerevisiae S288c)TBA
LigandPNGBDBM50070942((-)-Epigallocatechin gallate | (-)-Epigallocatechi...)
Affinity DataIC50:  3.00E+6nMAssay Description:Inhibition of Saccharomyces cerevisiae DNA topoisomerase 2More data for this Ligand-Target Pair
In DepthDetails Article