Compile Data Set for Download or QSAR
maximum 50k data
Found 101 Enz. Inhib. hit(s) with all data for assayid = 1 entry = 3120
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391883(US10301253, Example 33 | methyl 4-((4-(((2',3'- di...)
Affinity DataIC50:  12.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391892(N-((1-methylpiperidin-4- yl)methyl)-2',3'- dihydro...)
Affinity DataIC50:  25.1nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 90 | US10301253, Example 91)
Affinity DataIC50:  29.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391919(N-(2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2...)
Affinity DataIC50:  30.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391955(US10301253, Example 107)
Affinity DataIC50:  30.9nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391911(N-(3- (aminomethyl)cyclobutyl)- 2',3'- dihydrospir...)
Affinity DataIC50:  31.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391912(N-(piperidin-4-ylmethyl)- 2',3'- dihydrospiro[cycl...)
Affinity DataIC50:  32.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391921(6'-methyl-N-(piperidin-4- ylmethyl)-2',3'- dihydro...)
Affinity DataIC50:  34.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391885(N-((tetrahydro-2H-pyran-4- yl)methyl)-3',4'-dihydr...)
Affinity DataIC50:  37nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391902(N-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- nap...)
Affinity DataIC50:  38.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391913(5'-chloro-N-(piperidin-4- ylmethyl)-2',3'- dihydro...)
Affinity DataIC50:  40.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391897(3-[(spiro[cyclopropane-2,1'- indane]-1- ylamino)me...)
Affinity DataIC50:  43.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391920(2-((piperidin-4- ylmethyl)amino)-2',3'- dihydrospi...)
Affinity DataIC50:  44nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391918(N-(2-(azetidin-3-yl)ethyl)-6'- chloro-2',3'- dihyd...)
Affinity DataIC50:  46.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391917(N-(3- (aminomethyl)cyclobutyl)-6'- chloro-2',3'- d...)
Affinity DataIC50:  48.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391910(6'-chloro-N-(piperidin-4- ylmethyl)-2',3'- dihydro...)
Affinity DataIC50:  48.9nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391899(N-((1-(4- (methylsulfonyl) benzyl)piperidin-4- yl)...)
Affinity DataIC50:  50nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391925(N1-(6''-chloro-2'',3''- dihydrospiro[cyclopropane-...)
Affinity DataIC50:  57.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391929(6''-fluoro-N-(piperidin-4- ylmethyl)-2'',3''- dihy...)
Affinity DataIC50:  57.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391929(6''-fluoro-N-(piperidin-4- ylmethyl)-2'',3''- dihy...)
Affinity DataIC50:  58.4nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391916(N-(piperidin-4-ylmethyl)-6'- (pyridin-3-yl)-2',3'-...)
Affinity DataIC50:  60.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391925(N1-(6''-chloro-2'',3''- dihydrospiro[cyclopropane-...)
Affinity DataIC50:  64.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391899(N-((1-(4- (methylsulfonyl) benzyl)piperidin-4- yl)...)
Affinity DataIC50:  64.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391864(6'-bromo-2',3'- dihydrospiro [cyclopropane- 1,1'-i...)
Affinity DataIC50:  67.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391925(N1-(6''-chloro-2'',3''- dihydrospiro[cyclopropane-...)
Affinity DataIC50:  81nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391896(N-((1-methyl-1H-pyrazol-4- yl)methyl)-2',3'- dihyd...)
Affinity DataIC50:  81.3nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391901(Boc Deprotection | US10301253, Example 52)
Affinity DataIC50:  81.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391922(6'-(1-methyl-1H-pyrazol-4- yl)-N-(piperidin-4-ylme...)
Affinity DataIC50:  84nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391915(N1-(6'-chloro-2',3'- dihydrospiro[cyclopropane- 1,...)
Affinity DataIC50:  85.1nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391914(4'-chloro-N-(piperidin-4- ylmethyl)-2',3'- dihydro...)
Affinity DataIC50:  88.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391925(N1-(6''-chloro-2'',3''- dihydrospiro[cyclopropane-...)
Affinity DataIC50:  89.6nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391888(N-((1-methyl-1H-pyrazol-3- yl)methyl)-2',3'- dihyd...)
Affinity DataIC50:  93.7nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391889(N-(pyridin-3-ylmethyl)-3',4'- dihydro-2'H- spiro[c...)
Affinity DataIC50:  99.5nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391882(US10301253, Example 32 | methyl 4-((4-(((3',4'- di...)
Affinity DataIC50:  101nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391904(5'-(benzyloxy)-N-(piperidin- 4-ylmethyl)-2',3'- di...)
Affinity DataIC50:  103nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391859(6'-chloro-2',3'- dihydrospiro [cyclopropane- 1,1'-...)
Affinity DataIC50:  107nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391951(US10301253, Example 103)
Affinity DataIC50:  113nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391903(N1-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- na...)
Affinity DataIC50:  116nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391909(N-(2-(piperidin-4-yl)ethyl)- 3',4'-dihydro-2'H- sp...)
Affinity DataIC50:  128nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391906(N-(piperidin-3-ylmethyl)- 3',4'-dihydro-2'H- spiro...)
Affinity DataIC50:  144nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391947(US10301253, Example 99)
Affinity DataIC50:  151nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391938(US10301253, Example 90 | US10301253, Example 91)
Affinity DataIC50:  184nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391867(Boc Deprotection | US10301253, Example 17)
Affinity DataIC50:  218nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391870(2-amino-2',3'- dihydrospiro[cyclopropane- 1,1'-ind...)
Affinity DataIC50:  250nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391934(N1-(3',4'-dihydro-2'H- spiro[cyclopropane-1,1'- na...)
Affinity DataIC50:  253nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391894(N-(2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2...)
Affinity DataIC50:  273nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391924(7'-fluoro-N-(piperidin-4- ylmethyl)-3',4'-dihydro-...)
Affinity DataIC50:  288nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391950(4-((4-(((2',3'- dihydrospiro[cyclopropane- 1,1'-in...)
Affinity DataIC50:  289nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391881(Reductive Amination | US10301253, Example 31)
Affinity DataIC50:  295nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM391933(US10301253, Example 85)
Affinity DataIC50:  311nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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