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maximum 50k data
Found 29 Enz. Inhib. hit(s) with all data for assayid = 2 entry = 7439
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195013(US9206198, 78 | US9206198, 79)
Affinity DataIC50:  3nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194963(US9206198, 18)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194967(US9206198, 22)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194951(US9206198, 5)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194956(US9206198, 9)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194954(US9206198, 7)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194968(US9206198, 23)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195014(US9206198, 80 | US9206198, 81)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195012(US9206198, 76 | US9206198, 77)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195011(US9206198, 74 | US9206198, 75)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194992(US9206198, 53C)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194970(US9206198, 25)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194958(US9206198, 11)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195026(US9206198, 30)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195005(US9206198, 66)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194962(US9206198, 17)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194990(US9206198, 51)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195033(US9206198, 67)
Affinity DataIC50:  20nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195023(US9206198, 12)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195006(US9206198, 69)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194957(US9206198, 10)
Affinity DataIC50:  30nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194960(US9206198, 15)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195016(US9206198, 83)
Affinity DataIC50:  50nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194991(US9206198, 52)
Affinity DataIC50:  60nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194959(US9206198, 13)
Affinity DataIC50:  60nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194949(US9206198, 3)
Affinity DataIC50:  70nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM195024(US9206198, 14)
Affinity DataIC50:  100nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194966(US9206198, 21)
Affinity DataIC50:  390nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM194969(US9206198, 24)
Affinity DataIC50:  620nMpH: 7.4 T: 2°CAssay Description:Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent