Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for assayid = 6 entry = 50022114
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231682(CHEMBL251862 | N-((2S,3R)-4-((S)-1-(cyclohexylamin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231676(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-(3-methox...)
Affinity DataIC50:  14nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231685(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(2-...)
Affinity DataIC50:  17nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231694(CHEMBL402348 | N-((2S,3R)-4-(3-(trifluoromethoxy)b...)
Affinity DataIC50:  20nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231698(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(6-methylhep...)
Affinity DataIC50:  33nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231688(CHEMBL252458 | N-((2S,3R)-4-(2,6-dimethylheptan-2-...)
Affinity DataIC50:  33nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM29756(CHEMBL403429 | hydroxyethylamine derivative, 6)
Affinity DataIC50:  40nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231680(CHEMBL252656 | N-((2S,3R)-4-(3-methoxybenzylamino)...)
Affinity DataIC50:  43nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231689(CHEMBL253719 | N-((2S,3R)-4-(3-chlorobenzylamino)-...)
Affinity DataIC50:  83nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231686(CHEMBL403820 | N-((2S,3R)-4-(3,5-dimethoxybenzylam...)
Affinity DataIC50:  100nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231690(CHEMBL253060 | N-((2S,3R)-4-((S)-2,3-dihydro-1H-in...)
Affinity DataIC50:  160nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231678(CHEMBL252057 | N-((2S,3R)-4-(cyclohexylamino)-3-hy...)
Affinity DataIC50:  180nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231673(CHEMBL402171 | N-((2S,3R)-4-((1-ethyl-1H-pyrazol-4...)
Affinity DataIC50:  230nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231684(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(5-methylhex...)
Affinity DataIC50:  305nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231677(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-((6-methoxyp...)
Affinity DataIC50:  330nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231687(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(2-methylhep...)
Affinity DataIC50:  550nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231697(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(phenethylam...)
Affinity DataIC50:  600nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231679(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(te...)
Affinity DataIC50:  650nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231699(CHEMBL252860 | N-((2S,3R)-4-(benzylamino)-3-hydrox...)
Affinity DataIC50:  760nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231683(3-(ethylamino)-N-((2S,3R)-3-hydroxy-4-(1-isobutoxy...)
Affinity DataIC50:  790nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231674(CHEMBL430400 | N-((2S,3R)-4-(cycloheptylamino)-3-h...)
Affinity DataIC50:  1.12E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231693(CHEMBL429668 | N-((2S,3R)-4-(2-methoxybenzylamino)...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231681(3-(ethylamino)-N-((2S,3R)-3-hydroxy-1-phenyl-4-(ph...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231695(CHEMBL404500 | N-((2S,3R)-4-(4-methoxybenzylamino)...)
Affinity DataIC50:  2.09E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231675(CHEMBL402122 | N-((2S,3R)-4-(cyclopentylamino)-3-h...)
Affinity DataIC50:  2.45E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231691(CHEMBL402120 | N-((2S,3R)-4-((S)-1-(cyclohexylamin...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231696(CHEMBL252262 | N-((2S,3R)-4-(cyclohexylmethylamino...)
Affinity DataIC50:  5.89E+3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50231692(CHEMBL252495 | N-((2S,3R)-4-((R)-2,3-dihydro-1H-in...)
Affinity DataIC50:  3.47E+4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed