Affinity DataIC50: 4.70nMAssay Description:Inhibition of NEDD8 (unknown origin) assessed as decrease in formation of E2-UBL thioester reaction productMore data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic subunit(Homo sapiens)
St. Jude Children'S Research Hospital
Curated by ChEMBL
St. Jude Children'S Research Hospital
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant His-tagged NAE1 expressed in baculovirus expression system after 90 mins in presence of FLAG-tagged NEDD8 by TR-FRET ...More data for this Ligand-Target Pair
TargetNEDD8-activating enzyme E1 catalytic/regulatory subunit(Homo sapiens)
University Of Macau
Curated by ChEMBL
University Of Macau
Curated by ChEMBL
Affinity DataEC50: 3.40E+3nMAssay Description:Inhibition of NAE-mediated Ubcl2-NEDD8 conjugation in human Caco2 cells after 16 hrs by Western blot analysisMore data for this Ligand-Target Pair