Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science
Curated by ChEMBL
National Institute Of Biological Science
Curated by ChEMBL
Affinity DataIC50: 456nMAssay Description:Inhibition of N-terminal His6-SUMO tagged recombinant human PDK2 using [32P]-gamma-ATP assessed as decrease in incorporation of radioactivity into E1...More data for this Ligand-Target Pair
3D Structure (crystal)Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science
Curated by ChEMBL
National Institute Of Biological Science
Curated by ChEMBL
Affinity DataIC50: 800nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science
Curated by ChEMBL
National Institute Of Biological Science
Curated by ChEMBL
Affinity DataIC50: 800nMAssay Description:Inhibition of PDHK2 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science
Curated by ChEMBL
National Institute Of Biological Science
Curated by ChEMBL
Affinity DataKd: 156nMAssay Description:Binding affinity to N-terminal His6-SUMO tagged recombinant human PDK2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
National Institute Of Biological Science
Curated by ChEMBL
National Institute Of Biological Science
Curated by ChEMBL
Affinity DataKd: 239nMpH: 7.5 T: 2°CAssay Description:The PDK2 or Hsp90 N-terminal domain protein was dialyzed against 1 liter of thedialysis buffer containing 50 mM Tris-Cl, pH 7.5, 50 mM KCl, 1 mM MgCl...More data for this Ligand-Target Pair
