Compile Data Set for Download or QSAR
Found 730 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4-kinase beta'
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200009(CHEMBL3923414)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCOCC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H27ClN6O5S/c1-14-21(29-22(26-14)17(13-20(23)27-29)25-7-6-24-15(2)30)16-4-5-18(33-3)19(12-16)35(31,32)28-8-10-34-11-9-28/h4-5,12-13,25H,6-11H2,1-3H3,(H,24,30)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1
Show InChI InChI=1S/C22H22N8O2S/c1-32-16-6-4-15(5-7-16)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)33-19(26-17)14-3-2-8-24-13-14/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200098(CHEMBL3930509)
Show SMILES COc1ccc(cc1S(=O)(=O)N(C)C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C20H25ClN6O4S/c1-12-19(14-6-7-16(31-5)17(10-14)32(29,30)26(3)4)27-20(24-12)15(11-18(21)25-27)23-9-8-22-13(2)28/h6-7,10-11,23H,8-9H2,1-5H3,(H,22,28)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457851(CHEMBL4205416)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1
Show InChI InChI=1S/C22H22N8O2S/c1-32-16-6-4-15(5-7-16)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)33-19(26-17)14-3-2-8-24-13-14/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28)
Affinity DataIC50: 4nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Show SMILES CNC(=O)c1cc(ccc1Cl)-c1ccnc(c1)C(=O)NCc1cccc(c1)-n1cccn1
Show InChI InChI=1S/C24H20ClN5O2/c1-26-23(31)20-13-17(6-7-21(20)25)18-8-10-27-22(14-18)24(32)28-15-16-4-2-5-19(12-16)30-11-3-9-29-30/h2-14H,15H2,1H3,(H,26,31)(H,28,32)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)c1
Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-14(11)22-19(27)25-6-7-26(12(2)9-25)16-15-17(29-10-21-15)24-18(20)23-16/h4-5,8,10,12H,6-7,9H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1
Show InChI InChI=1S/C22H22N8OS/c1-14-4-6-16(7-5-14)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)32-19(26-17)15-3-2-8-24-13-15/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)ncc23)c(C)c1
Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression systemMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200012(CHEMBL3958915)
Show SMILES CCC(CO)NS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCc3ccnc(CC)c3)cc(Cl)nn12
Show InChI InChI=1S/C26H31ClN6O4S/c1-5-19-11-17(9-10-28-19)14-29-21-13-24(27)31-33-25(16(3)30-26(21)33)18-7-8-22(37-4)23(12-18)38(35,36)32-20(6-2)15-34/h7-13,20,29,32,34H,5-6,14-15H2,1-4H3
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50492527(CHEMBL2407818)
Show SMILES Cc1nc2c(NCc3cccc(c3)S(C)(=O)=O)nccn2c1-c1ccc(O)c(F)c1
Show InChI InChI=1S/C21H19FN4O3S/c1-13-19(15-6-7-18(27)17(22)11-15)26-9-8-23-20(21(26)25-13)24-12-14-4-3-5-16(10-14)30(2,28)29/h3-11,27H,12H2,1-2H3,(H,23,24)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of recombinant PI4K3beta (unknown origin) using PI:PS as substrate after 75 to 90 mins by scintillation counting analysis in presence of [...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199891(CHEMBL3920652)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCC(O)CC2)ccn1
Show InChI InChI=1S/C27H31ClN6O4S/c1-4-20-13-18(7-10-29-20)16-30-22-15-25(28)32-34-26(17(2)31-27(22)34)19-5-6-23(38-3)24(14-19)39(36,37)33-11-8-21(35)9-12-33/h5-7,10,13-15,21,30,35H,4,8-9,11-12,16H2,1-3H3
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457867(CHEMBL4203566)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sncc23)c(C)c1
Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-15(11)22-19(27)25-6-7-26(12(2)10-25)16-14-9-21-29-17(14)24-18(20)23-16/h4-5,8-9,12H,6-7,10H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sccc23)c(C)c1
Show InChI InChI=1S/C20H24N6O2S/c1-12-10-14(28-3)4-5-16(12)22-20(27)25-7-8-26(13(2)11-25)17-15-6-9-29-18(15)24-19(21)23-17/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,22,27)(H2,21,23,24)/t13-/m0/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200000(CHEMBL3911522)
Show SMILES CCC(CO)NS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H29ClN6O5S/c1-5-16(12-30)28-35(32,33)19-10-15(6-7-18(19)34-4)21-13(2)26-22-17(11-20(23)27-29(21)22)25-9-8-24-14(3)31/h6-7,10-11,16,25,28,30H,5,8-9,12H2,1-4H3,(H,24,31)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457876(CHEMBL4209793)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)cnc23)c(C)c1
Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-15(12)23-20(29)27-7-8-28(13(2)10-27)18-16-17(24-19(21)25-18)26(3)11-22-16/h5-6,9,11,13H,7-8,10H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457868(CHEMBL4202450)
Show SMILES Cc1nn2c(NCc3ccnc(C)c3)cc(C)nc2c1-c1ccc(Cl)c(NS(C)(=O)=O)c1
Show InChI InChI=1S/C22H23ClN6O2S/c1-13-9-16(7-8-24-13)12-25-20-10-14(2)26-22-21(15(3)27-29(20)22)17-5-6-18(23)19(11-17)28-32(4,30)31/h5-11,25,28H,12H2,1-4H3
Affinity DataIC50: 8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457850(CHEMBL4203041)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)cc1
Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23)/t11-/m0/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457853(CHEMBL4215340)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)c1
Show InChI InChI=1S/C19H23N7O2S/c1-11-8-13(28-3)4-5-14(11)22-19(27)25-6-7-26(12(2)9-25)16-15-17(29-10-21-15)24-18(20)23-16/h4-5,8,10,12H,6-7,9H2,1-3H3,(H,22,27)(H2,20,23,24)/t12-/m0/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50005005(CHEMBL2397317)
Show SMILES COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12
Show InChI InChI=1S/C22H29N5O3/c1-15-13-20(23-7-8-26-9-11-30-12-10-26)27-22(24-15)21(16(2)25-27)17-5-6-18(28-3)19(14-17)29-4/h5-6,13-14,23H,7-12H2,1-4H3
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200097(CHEMBL3939697)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCC=C)ccn1
Show InChI InChI=1S/C25H27ClN6O3S/c1-5-10-29-36(33,34)22-13-18(7-8-21(22)35-4)24-16(3)30-25-20(14-23(26)31-32(24)25)28-15-17-9-11-27-19(6-2)12-17/h5,7-9,11-14,28-29H,1,6,10,15H2,2-4H3
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457860(CHEMBL4207851)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3scnc23)c(C)c1
Show InChI InChI=1S/C18H21N7O2S/c1-11-9-12(27-2)3-4-13(11)21-18(26)25-7-5-24(6-8-25)15-14-16(28-10-20-14)23-17(19)22-15/h3-4,9-10H,5-8H2,1-2H3,(H,21,26)(H2,19,22,23)
Affinity DataIC50: 9nMAssay Description:GRAC: human Y1 selective antagonistMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199889(CHEMBL3957128)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCN(C)C)ccn1
Show InChI InChI=1S/C26H32ClN7O3S/c1-6-20-13-18(9-10-28-20)16-29-21-15-24(27)32-34-25(17(2)31-26(21)34)19-7-8-22(37-5)23(14-19)38(35,36)30-11-12-33(3)4/h7-10,13-15,29-30H,6,11-12,16H2,1-5H3
Affinity DataIC50: 9nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457870(CHEMBL1652677)
Show SMILES Nc1nc(N2CCN(CC2)C(=O)COc2ccc(Cl)cc2)c2nc(sc2n1)-c1cccnc1
Show InChI InChI=1S/C22H20ClN7O2S/c23-15-3-5-16(6-4-15)32-13-17(31)29-8-10-30(11-9-29)19-18-21(28-22(24)27-19)33-20(26-18)14-2-1-7-25-12-14/h1-7,12H,8-11,13H2,(H2,24,27,28)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457855(CHEMBL4211181)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3n(C)ncc23)c(C)c1
Show InChI InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457871(CHEMBL4210308)
Show SMILES COc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2ccccc2)cc1
Show InChI InChI=1S/C23H23N7O2S/c1-32-17-9-7-16(8-10-17)25-23(31)30-13-11-29(12-14-30)19-18-21(28-22(24)27-19)33-20(26-18)15-5-3-2-4-6-15/h2-10H,11-14H2,1H3,(H,25,31)(H2,24,27,28)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200004(CHEMBL3959713)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2cccc(c2)S(=O)(=O)N(C)C)ccn1
Show InChI InChI=1S/C23H25ClN6O2S/c1-5-18-11-16(9-10-25-18)14-26-20-13-21(24)28-30-22(15(2)27-23(20)30)17-7-6-8-19(12-17)33(31,32)29(3)4/h6-13,26H,5,14H2,1-4H3
Affinity DataIC50: 13nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457848(CHEMBL4215244)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3sccc23)c(C)c1
Show InChI InChI=1S/C20H24N6O2S/c1-12-10-14(28-3)4-5-16(12)22-20(27)25-7-8-26(13(2)11-25)17-15-6-9-29-18(15)24-19(21)23-17/h4-6,9-10,13H,7-8,11H2,1-3H3,(H,22,27)(H2,21,23,24)/t13-/m0/s1
Affinity DataIC50: 13nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200109(CHEMBL3974986)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCC#C)ccn1
Show InChI InChI=1S/C25H25ClN6O3S/c1-5-10-29-36(33,34)22-13-18(7-8-21(22)35-4)24-16(3)30-25-20(14-23(26)31-32(24)25)28-15-17-9-11-27-19(6-2)12-17/h1,7-9,11-14,28-29H,6,10,15H2,2-4H3
Affinity DataIC50: 13nMAssay Description:Inhibition of 6xHisGB1 tagged PI4KB (unknown origin) expressed in Escherichia coli BL21 StarMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199998(CHEMBL3902513)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCC(CO)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H31ClN6O5S/c1-15-23(31-24(28-15)19(13-22(25)29-31)27-9-8-26-16(2)33)18-4-5-20(36-3)21(12-18)37(34,35)30-10-6-17(14-32)7-11-30/h4-5,12-13,17,27,32H,6-11,14H2,1-3H3,(H,26,33)
Affinity DataIC50: 15nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200101(CHEMBL3947384)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NC2CCC(N)CC2)ccn1
Show InChI InChI=1S/C28H34ClN7O3S/c1-4-21-13-18(11-12-31-21)16-32-23-15-26(29)34-36-27(17(2)33-28(23)36)19-5-10-24(39-3)25(14-19)40(37,38)35-22-8-6-20(30)7-9-22/h5,10-15,20,22,32,35H,4,6-9,16,30H2,1-3H3
Affinity DataIC50: 16nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457870(CHEMBL1652677)
Show SMILES Nc1nc(N2CCN(CC2)C(=O)COc2ccc(Cl)cc2)c2nc(sc2n1)-c1cccnc1
Show InChI InChI=1S/C22H20ClN7O2S/c23-15-3-5-16(6-4-15)32-13-17(31)29-8-10-30(11-9-29)19-18-21(28-22(24)27-19)33-20(26-18)14-2-1-7-25-12-14/h1-7,12H,8-11,13H2,(H2,24,27,28)
Affinity DataIC50: 16nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200005(CHEMBL3929556)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCOC)ccn1
Show InChI InChI=1S/C25H29ClN6O4S/c1-5-19-12-17(8-9-27-19)15-28-20-14-23(26)31-32-24(16(2)30-25(20)32)18-6-7-21(36-4)22(13-18)37(33,34)29-10-11-35-3/h6-9,12-14,28-29H,5,10-11,15H2,1-4H3
Affinity DataIC50: 17nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457886(CHEMBL4211696)
Show SMILES CNC(=O)c1cc(ccc1Cl)-c1ccnc(c1)C(=O)NCc1cccc(c1)-n1cccn1
Show InChI InChI=1S/C24H20ClN5O2/c1-26-23(31)20-13-17(6-7-21(20)25)18-8-10-27-22(14-18)24(32)28-15-16-4-2-5-19(12-16)30-11-3-9-29-30/h2-14H,15H2,1H3,(H,26,31)(H,28,32)
Affinity DataIC50: 18nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200105(CHEMBL3894217)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCOCC2)ccn1
Show InChI InChI=1S/C26H29ClN6O4S/c1-4-20-13-18(7-8-28-20)16-29-21-15-24(27)31-33-25(17(2)30-26(21)33)19-5-6-22(36-3)23(14-19)38(34,35)32-9-11-37-12-10-32/h5-8,13-15,29H,4,9-12,16H2,1-3H3
Affinity DataIC50: 18nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457862(CHEMBL4204100)
Show SMILES COc1ccc(NC(=O)N2CCN(C(C)C2)c2nc(N)nc3scnc23)cc1
Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50341209(9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phen...)
Show SMILES Nc1ccc(cn1)-c1ccc2ncc3ccc(=O)n(-c4cccc(c4)C(F)(F)F)c3c2c1
Show InChI InChI=1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
Affinity DataIC50: 18nMAssay Description:Inhibition of PI4K betaMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457854(CHEMBL4206816)
Show SMILES Cc1ccc(NC(=O)N2CCN(CC2)c2nc(N)nc3sc(nc23)-c2cccnc2)cc1
Show InChI InChI=1S/C22H22N8OS/c1-14-4-6-16(7-5-14)25-22(31)30-11-9-29(10-12-30)18-17-20(28-21(23)27-18)32-19(26-17)15-3-2-8-24-13-15/h2-8,13H,9-12H2,1H3,(H,25,31)(H2,23,27,28)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200103(CHEMBL3948449)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)n2cccn2)ccn1
Show InChI InChI=1S/C25H24ClN7O3S/c1-4-19-12-17(8-10-27-19)15-28-20-14-23(26)31-33-24(16(2)30-25(20)33)18-6-7-21(36-3)22(13-18)37(34,35)32-11-5-9-29-32/h5-14,28H,4,15H2,1-3H3
Affinity DataIC50: 19nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Show SMILES CC(=O)\N=c1\[nH]c(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)NCCO
Show InChI InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
Affinity DataIC50: 19nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200096(CHEMBL3893537)
Show SMILES COc1ccc(cc1S(=O)(=O)NCC=C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H25ClN6O4S/c1-5-8-25-33(30,31)18-11-15(6-7-17(18)32-4)20-13(2)26-21-16(12-19(22)27-28(20)21)24-10-9-23-14(3)29/h5-7,11-12,24-25H,1,8-10H2,2-4H3,(H,23,29)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457866(CHEMBL4207928)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)c(C)n1
Show InChI InChI=1S/C18H22N8O2S/c1-10-8-25(18(27)22-12-4-5-13(28-3)21-11(12)2)6-7-26(10)15-14-16(29-9-20-14)24-17(19)23-15/h4-5,9-10H,6-8H2,1-3H3,(H,22,27)(H2,19,23,24)/t10-/m0/s1
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human full length GST-tagged PI4K3beta expressed in baculovirus expression system using PI lipid kinase substrate after 60 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50005004(CHEMBL2397309)
Show SMILES CO[C@H]1CC[C@H](CC1)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1
Show InChI InChI=1S/C17H22N4O2S/c1-10-15(12-5-8-14(18)19-9-12)24-17(20-10)21-16(22)11-3-6-13(23-2)7-4-11/h5,8-9,11,13H,3-4,6-7H2,1-2H3,(H2,18,19)(H,20,21,22)/t11-,13+
Affinity DataIC50: 22nMAssay Description:Inhibition of PI4K3beta (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199892(CHEMBL3889874)
Show SMILES COc1ccc(cc1S(=O)(=O)NCCO)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C20H25ClN6O5S/c1-12-19(14-4-5-16(32-3)17(10-14)33(30,31)24-8-9-28)27-20(25-12)15(11-18(21)26-27)23-7-6-22-13(2)29/h4-5,10-11,23-24,28H,6-9H2,1-3H3,(H,22,29)
Affinity DataIC50: 22nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457862(CHEMBL4204100)
Show SMILES COc1ccc(NC(=O)N2CCN(C(C)C2)c2nc(N)nc3scnc23)cc1
Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23)
Affinity DataIC50: 23nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199996(CHEMBL3915835)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCc3ccncc3)cc(Cl)nn12
Show InChI InChI=1S/C21H21ClN6O2S/c1-14-20(16-5-4-6-17(11-16)31(29,30)27(2)3)28-21(25-14)18(12-19(22)26-28)24-13-15-7-9-23-10-8-15/h4-12,24H,13H2,1-3H3
Affinity DataIC50: 26nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199999(CHEMBL3986552)
Show SMILES COc1ccc(cc1S(=O)(=O)NC1CCC(N)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H32ClN7O4S/c1-14-23(32-24(29-14)19(13-22(25)30-32)28-11-10-27-15(2)33)16-4-9-20(36-3)21(12-16)37(34,35)31-18-7-5-17(26)6-8-18/h4,9,12-13,17-18,28,31H,5-8,10-11,26H2,1-3H3,(H,27,33)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200007(CHEMBL3925101)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N(C)C)ccn1
Show InChI InChI=1S/C24H27ClN6O3S/c1-6-18-11-16(9-10-26-18)14-27-19-13-22(25)29-31-23(15(2)28-24(19)31)17-7-8-20(34-5)21(12-17)35(32,33)30(3)4/h7-13,27H,6,14H2,1-5H3
Affinity DataIC50: 27nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50042924(CHEMBL1229535)
Show SMILES CC(=O)\N=c1\[nH]c(C)c(s1)-c1ccc(Cl)c(c1)S(=O)(=O)NCCO
Show InChI InChI=1S/C14H16ClN3O4S2/c1-8-13(23-14(17-8)18-9(2)20)10-3-4-11(15)12(7-10)24(21,22)16-5-6-19/h3-4,7,16,19H,5-6H2,1-2H3,(H,17,18,20)
Affinity DataIC50: 28nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50457850(CHEMBL4203041)
Show SMILES COc1ccc(NC(=O)N2CCN([C@@H](C)C2)c2nc(N)nc3scnc23)cc1
Show InChI InChI=1S/C18H21N7O2S/c1-11-9-24(18(26)21-12-3-5-13(27-2)6-4-12)7-8-25(11)15-14-16(28-10-20-14)23-17(19)22-15/h3-6,10-11H,7-9H2,1-2H3,(H,21,26)(H2,19,22,23)/t11-/m0/s1
Affinity DataIC50: 31nMAssay Description:Inhibition of PI4K3beta in human PBMC assessed as reduction in mitomycin-C treated human RPMI1788 cells-stimulated lymphocyte proliferation by measur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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