Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 2I4J
TargetProtein Wiz(Homo sapiens)
Takeda Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 6130BDBM6130((S)-4-((6-(1-cyclopropyl-1H-pyrazol-4-yl)- 1-methy...)
Affinity DataEC50: <10nMAssay Description:Kd values were obtained by incubating His-PPARgamma-LBD with biotinylated peptide, europium-labeled anti-histidine antibody, and allophycocyanin-labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2026
Entry Details
US Patent

TargetPeroxisome proliferator-activated receptor gamma(Human)
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28762BDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataEC50:  70nMAssay Description:Agonist activity at human GAL4-fused PPARgamma ligand binding domain expressed in HepG2 cells after 20 hrs by luciferase reporter gene transactivatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28762BDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nMAssay Description:Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28762BDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKi:  88nM ΔG°:  -39.9kJ/molepH: 7.5 T: 2°CAssay Description:The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Istituto Tumori&Quot;Giovanni Paolo Ii&Quot

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28762BDBM28762((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...)
Affinity DataKd:  270nMAssay Description:Binding affinity to PPARgamma ligand binding domain by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)