Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 3O0G
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59194(4-aminothiazole, 2.0)
Affinity DataKi:  660nM IC50: 2.00E+3nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5(Human)
Harvard Medical School

LigandPNGBDBM59194(4-aminothiazole, 2.0)
Affinity DataKi:  690nMAssay Description:Cdk5, 33P-ATP and cofactors were added in the presence of tau protein. The reaction mixture was incubated to allow Cdk5 to transfer 33P from ATP to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 750nMAssay Description:Inhibition of CDK5/p25 assessed as [33P]gamma-ATP incorporation into peptide PKTPKKAKKL substrate after 45 mins by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 5 activator 1(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50340888((4-amino-2-(4-chlorophenylamino)thiazol-5-yl)(3-ni...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK5/P25 using full length tau as substrate by colorimetric ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)