Compile Data Set for Download or QSAR
Report error Found 2 Enz. Inhib. hit(s) for PDB: 3ZEP
TargetTyrosine-protein kinase JAK3(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433297(CHEMBL2376436)
Affinity DataIC50: 22nMAssay Description:Inhibition of JAK3 (unknown origin) using Biotin-KAIETDKEYYTVKD as substrate and [33Pgamma]ATP incubated for 10 mins prior to substrate addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetJAK3/JAK1(Human)
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50433297(CHEMBL2376436)
Affinity DataIC50: 700nMAssay Description:Inhibition of JAK1/3 in human PBMC expressing CD3 assessed as inhibition of IL2-induced STAT5a phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)