Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4B99
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM199090(XMD17-109 | US9676792, Compound 26)
Affinity DataEC50:  80nMAssay Description:Inhibition of EGF-stimulated ERK5 autophosphorylation in human HeLa cells preincubated with compound for 1 hrs followed by EGF stimulation for 17 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM199090(XMD17-109 | US9676792, Compound 26)
Affinity DataIC50: 82nMAssay Description:Inhibition of N-terminal 6His-tagged human ERK5 expressed in baculovirus infected Sf21 cells co-expressing HA-tagged human MEK5-DD using ARKKRRHPSGPP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM199090(XMD17-109 | US9676792, Compound 26)
Affinity DataIC50: 162nM EC50:  90nMpH: 7.5Assay Description:Kinase activity was determined in an assay volume of 40 μl in kinase buffer (50 mM Tris-HCl, pH 7.5, 0.1 mM EGTA, 1 mM 2-mercaptoethanol) contai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2018
Entry Details
US Patent
PDB3D3D Structure (crystal)