Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) for PDB: 4CRL
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 5nMAssay Description:Inhibition of CDK8/CCNC (unknown origin) using RBER-IRStide as substrate in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK19 (unknown origin) in presence of [gamma33P]ATP by radiometric methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type partial length human CDK11 (M1 to N360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 19(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type partial length human CDK11 (M1 to N360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK8 (unknown origin) assessed as reduction in RNAP2 C-terminal domain phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-C(Human)
University of South Australia

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataIC50: 12nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) using RBER-IRStide as substrate by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 8(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50248631(CHEMBL4080906)
Affinity DataKd:  17nMAssay Description:Binding affinity to wild-type partial length human CDK8 (M1 to T360 residues) expressed in bacterial expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)