Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) for PDB: 4FL6
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.0430nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.0500nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.0510nMAssay Description:Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.037549815 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.146nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.01 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.156nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.05 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.284nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.297nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.5 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  0.311nMAssay Description:Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation constant at 0.1 uM (Rvb = 0.1272 um2/s)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate incubated for 30 mins at room temperature followed by incubation under ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 40nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 peptide by Alpha-Screen methylated histone peptide competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 49nMAssay Description:Inhibition of L3MBTL3 (unknown origin) using H4K20me2 as substrate after 30 mins by LNCE-TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 50nMAssay Description:Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells assessed as reduction in recovery of fluorescence intensity measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 64nMAssay Description:Inhibition of L3MBTL3 (unknown origin) after 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Binding affinity to L3MBTL3 (unknown origin) by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Binding affinity to L3MBTL3 (unknown origin) by isothermal titration calorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Inhibition of L3MBTL3 (unknown origin) assessed as dissociation constant by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataKd:  120nMAssay Description:Binding affinity to His-tagged wild type L3MBTL3 (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLethal(3)malignant brain tumor-like protein 3(Human)
University of North Carolina Eshelman School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50440614(CHEMBL2426364)
Affinity DataIC50: 500nMAssay Description:Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells assessed as disruption of foci formation by immunofluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)