Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 4IQK
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKi:  250nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  370nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  500nMAssay Description:Binding affinity to Keap1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataIC50: 940nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction expressed in Escherichia coli BL21 codon plus cells using FITC-beta-DEETGEF-OH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataEC50:  1.46E+3nMAssay Description:Displacement of FITC-LDEETGEFL-NH2 from Keap1 Kelch domain (unknown origin) after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataIC50: 1.60E+3nMAssay Description:Binding affinity to His-tagged Keap1 DC domain (321 to 609 residues) (unknown origin) expressed in Escherichia coli assessed as reduction in protein ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  1.69E+3nMAssay Description:Binding affinity to biotinylated Keap1 DC domain (unknown origin) by biolayer interferometry assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  1.70E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) protein-protein interaction by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataKd:  1.70E+3nMAssay Description:Binding affinity to Keap1 Kelch domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataIC50: 1.70E+3nMAssay Description:Binding affinity to the Keap1 (321 to 609 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells by surface plasmon resonance assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataIC50: 2.70E+3nMAssay Description:Displacement of MR121-Nrf2 from human N-terminal His-tagged Kelch-DC domain of Keap1 (321 to 609) expressed in Escherichia coli BL21 (DE3) after 40 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50006931(CHEMBL2402207)
Affinity DataEC50:  5.80E+3nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) assessed as thermal stabiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)