Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 4MQS
TargetMuscarinic acetylcholine receptor M2(Pig)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataEC50:  0.0794nMAssay Description:Agonist activity at muscarinic M2 receptor in albino guinea pig left atrium assessed as stimulation of electrically-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Pig)
University of Milan

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataEC50:  0.166nMAssay Description:Agonist activity at muscarinic M3 receptor in albino guinea pig ileum assessed as stimulation of electrically-induced responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataEC50:  0.280nMAssay Description:Agonist activity at human recombinant muscarinic M2 receptor co-expressed with Galphaqi5-HA in African green monkey COS7 cells assessed as IP accumul...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q/T423H mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-NMS from wild-type human muscarinic M2 receptor expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y177Q mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 W422A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMuscarinic acetylcholine receptor M2(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50448377(CHEMBL3121473)
Affinity DataKi:  257nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 Y104A mutant expressed in Flp-In-CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/3/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)