Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 4O6E
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021717(CHEMBL3298414)
Affinity DataKi:  0.400nMAssay Description:Inhibition of 6-His tagged human ERK2 expressed in Escherichia coli measured over 30 mins by competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021717(CHEMBL3298414)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant N-terminal 6-His-tagged ERK2 expressed in Escherichia coli using S/T17 as substrate after 30 mins by spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 1(Human)
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50021717(CHEMBL3298414)
Affinity DataIC50: 45nMAssay Description:Inhibition of ERK2 in human HepG2 cells assessed as P90RSK phosphorylation at Ser380 after 1.5 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)