Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) for PDB: 4PJV
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PARP2 (unknown origin) using NAD as substrate incubated for 1 minMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal GST-tagged human PARP2 (2 to 583 residues) expressed in baculovirus infected Sf9 cells using histone mixture (H2A and H2B) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataKi:  0.850nMAssay Description:Inhibition of human PARP2 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataKi:  0.900nMAssay Description:Inhibition of PARP2 (unknown origin) after 1 min in presence of NAD by top count analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 1nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
West China Hospital of Sichuan University

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataIC50: 30nMAssay Description:Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)