Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 5AR0
TargetHeat shock cognate 71 kDa protein(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataKd:  720nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock cognate 71 kDa protein(Human)
The Institute of Cancer Research

Curated by ChEMBL
LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataKd:  724nMAssay Description:Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataKi:  1.29E+3nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:The assay was based on the fluorescence polarization of the unbound small binding partner will be low, and its binding to a larger binding partner wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHeat shock 70 kDa protein 1A(Human)
Vernalis (R&D)

LigandPNGBDBM32375(adenosine-derived inhibitor (Grp78), 9 | adenosine...)
Affinity DataIC50: 2.90E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescein-labeled ATP-based probe was utilized, which binds to the GST fused ATPase domain (amino acids 3-383) of HSP70, producing an increase in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)