Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 5KTX
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataIC50: 20nMAssay Description:Displacement of biotinylated histone H3K14 peptide ligand from human recombinant His-tagged CBP measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataIC50: 22nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataIC50: 410nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to NanoLuc luciferase conjugated human CBP expressed in HEK293 cells after overnight incubation by BRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataEC50:  910nMAssay Description:Inhibition of CBP in human MV-4-11 cells assessed as decrease in MYC expression incubated for 4 hrs measured by luminescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50200445(CHEMBL3897393 | US9763922, Example 300)
Affinity DataEC50:  1.90E+3nMAssay Description:Inhibition of CBP/EP300 in human MV4-11 cells assessed as inhibition of MYC expression measured after 4 hrs by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)