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Found
1
Enz. Inhib. hit(s) for PDB:
5LGE
Target
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H]
(Human)
Bayer
US Patent
Ligand
BDBM389289
(US9951027, 2-76-1)
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Affinity Data
IC50: 30nM
Assay Description:
mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...
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Target Info
PDB
UniProtKB/SwissProt
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Ligand Info
PC cid
PC sid
PDB
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In Depth
Date in BDB:
3/16/2020
Entry Details
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US Patent
PDB
3D Structure (crystal)
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