Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 5NHY
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandPNGBDBM50255583(CHEMBL4096813)
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to recombinant human full length N-terminal His tagged-MTH1 expressed in Escherichia coli at 3 mM by isothermal titration calorimetr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandPNGBDBM50255583(CHEMBL4096813)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of N-terminal His-tagged full-length recombinant human MTH1 (1 to 156 residues) expressed in Escherichia coli using 8-oxo-dGTP as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetOxidized purine nucleoside triphosphate hydrolase(Human)
Sprint Bioscience

Curated by ChEMBL
LigandPNGBDBM50255583(CHEMBL4096813)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human recombinant human His-tagged MTH1 expressed in Escherichia coli BL21 (DE3) using 8-oxo-dGTP as substrate incubated for 15 mins fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)