Compile Data Set for Download or QSAR
Report error Found 10 Enz. Inhib. hit(s) for PDB: 5OVI
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 6.60nMAssay Description:Inhibition of SOS1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataKd:  36nMAssay Description:Binding affinity to N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataKd:  36nMAssay Description:Binding affinity to human SOS1 (560 to 1049 residues) expressed in Escherichia coli by ITC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 53nMAssay Description:Inhibition of N-terminal His10-tagged wild-type recombinant human SOS1 catalytic domain (564 to 1049 residues) expressed in Escherichia coli assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 150nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in pERK level incubated for 24 hrs by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 180nMAssay Description:Inhibition of SOS1 in human K562 cells assessed as reduction in pERK level incubated for 60 mins by HTRF analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 200nMAssay Description:Inhibition of SOS1 in human Calu-1 cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSon of sevenless homolog 1(Human)
Jiangnan University

Curated by ChEMBL
LigandPNGBDBM50614629(BAY-293)
Affinity DataIC50: 410nMAssay Description:Inhibition of SOS1 in human HeLa cells assessed as reduction in RAS activation pretreated for 30 mins followed by EGF stimulation for 3 mins by G-LIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)