Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 5U1X
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50585248(CHEMBL2338352)
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human P2X7R expressed in HEK293 cells assessed as reduction in YO-PRO-1 iodide dye uptake preincubated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50585248(CHEMBL2338352)
Affinity DataIC50: 30nMAssay Description:Antagonist activity at P2X7 receptor in human THP-1 cells assessed as inhibition of ATP-induced IL-1beta secretion pretreated with LPS for 3 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetP2X purinoceptor 7(Human)
European Institute For Molecular Imaging (Eimi)

Curated by ChEMBL
LigandPNGBDBM50585248(CHEMBL2338352)
Affinity DataIC50: 35nMAssay Description:Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced calcium-flux measured after 60 mins by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)