Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 5UGH
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataKd:  170nMAssay Description:Binding affinity to MAT2a (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataIC50: 225nMAssay Description:Inhibition of MAT2A in human Huh-7 cells assessed as inhibition of S-adenosyl methionine production measured after 6 hrs by Rapid Fire Mass Spectrome...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataIC50: 412nMAssay Description:Inhibition of human MAT2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataIC50: 420nMAssay Description:Inhibition of N-terminal TEV cleavable 6His-tagged human MAT2A (1 to 395 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as S-adeno...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MAT2a in human NCI-H520 cells assessed as reduction in SAM production incubated for 6 hrs by RapidFire-Mass Spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetS-adenosylmethionine synthase isoform type-2(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50598612(CHEMBL337420)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of MAT2A in human NCI-H520 cells transfected with MAT2A empty vector assessed as inhibition of S-adenosyl methionine production measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)