Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 5UOY
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50: 27nMAssay Description:Inhibition of full length GST-tagged PDE1B (unknown origin) assessed as decrease in FAM-cAMP hydrolysis preincubated for 5 mins followed by FAM-cAMP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50: 100nMAssay Description:The selectivity of compounds of the present invention was determined using a panel of recombinant human PDEs and an in vitro enzymatic assay (BPS Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataEC50: <100nMT: 2°CAssay Description:The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or cGMP substrate, DMSO tolerance, and incubation time. Into e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM289621(6-(4-Methoxybenzyl)-9-((tetrahydro-2H-pyran-4-yl)m...)
Affinity DataIC50: 100nMT: 2°CAssay Description:PDE1B inhibition was determined by an IMAP TR-FRET assay. The IMAP TR-FRET PDE assay was optimized for concentration of enzyme, Calmodulin, cAMP or c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2019
Entry Details
US Patent
PDB3D3D Structure (crystal)