TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataKd: 324nMAssay Description:Binding affinity to recombinant human N-terminal His6-tagged Myt1 kinase domain (75 to 361 residues) by isothermal titration calorimetryMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataKi: 470nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataKi: 601nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Human)
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 4.94E+3nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
