Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 5X8X
TargetNuclear receptor ROR-gamma(Mouse)
Central Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  29nMAssay Description:Inhibition of mouse RORgamma ligand binding domain (Isoleucine 251 to Lysine 516) expressed in CHOK1 cells incubated for 2 days by Gal4 luciferase re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  34nMAssay Description:Inhibition of human GAL4-fused RORgamma LBD transcriptional activity expressed in CHOK1 cells after 2 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  34nMAssay Description:Inhibition of GAL4 DNA-binding domain fused RORgamma (unknown origin) transfected in CHO-K1 cells incubated for 2 days by luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  34nMAssay Description:Inhibition of human RORgamma ligand binding domain (Serine 253 to Lysine 518 residues) expressed in CHOK1 cells incubated for 2 days by Gal4 lucifera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  160nMAssay Description:Inverse agonist activity at human RORgammat LBD (265 to 507 residues) expressed in sf9 cells assessed as corepressor peptide recruiting activity by F...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNuclear receptor ROR-gamma(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50153594(CHEMBL3774855)
Affinity DataEC50:  200nMAssay Description:Inhibition of human GST-tagged RORgamma ligand binding domain (253 to 518 residues) expressed in sf9 cells using biotin-EEPSLLKKLLLAPA by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)