Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 6BBV
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal His-tagged human JAK2 catalytic domain incubated for 20 mins in presence of TK substrate-biotin by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 163nMAssay Description:Inhibition of JAK1/JAK2/TYK2 in CD14+ human whole blood assessed as reduction in IL-6 induced STAT1 phosphorylation preincubated for 45 mins followed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 163nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IFNgamma induced STAT1 phosphorylation preincubated for 45 mins followed by IFN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK1/JAK2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 271nMAssay Description:Inhibition of JAK2/JAK1 in human whole blood assessed as reduction in IL-27 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-27 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 412nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 803nMAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 803nMpH: 7.4 T: 2°CAssay Description:Test article and assay controls were added to a 384-well plate. Reaction mixtures contained 20 mM HEPES, pH 7.4, 10 mM magnesium chloride, 0.01% bovi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2015
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 803nMAssay Description:Inhibition of recombinant human JAK2 using FITC-KGGEEEEYFELVKK as substrate in presence of 1 mM ATP by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JAK2 in human STAT5-irf1-bla TF1 cells assessed as reduction in EPO-induced STAT5-signalling pre-incubated for 1 hrs before EPO additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Gvk Biosciences

Curated by ChEMBL
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 7.18E+3nMAssay Description:Inhibition of JAK2 in CD34+ human whole blood assessed as reduction in EOP induced STAT5 phosphorylation preincubated for 45 mins followed by EOP add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-12 induced STAT4 phosphorylation preincubated for 45 mins followed by IL-12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM159748(US9035074, 2 | US10966980, Example 2)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of JAK2/TYK2 in human whole blood assessed as reduction in IL-23 induced STAT3 phosphorylation preincubated for 45 mins followed by IL-23 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)