Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 6DXK
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 7.5nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells assessed as inhibition of glucocorticoid receptor-dexamethasone coacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 8nMAssay Description:Displacement of fluormone tracer from full length human recombinant glucocorticoid receptor expressed in baculovirus expression system incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human glucocorticoid receptor expressed in CHO-K1 cells harboring firefly luciferase gene after 20 hrs by One-Glo luciferase r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 100nMAssay Description:Cell Line: CHO-K1-GR-MMTV-Luc reporter cellsCulture Media: DMEM (with phenol red)+10% FBSAssay Media: DMEM (without phenol red)+10% CSSCulture CHO-K1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataIC50: 100nMAssay Description:Cell Line: CHO-K1-GR-MMTV-Luc reporter cellsCulture Media: DMEM (with phenol red)+10% FBSAssay Media: DMEM (without phenol red)+10% CSSCulture CHO-K1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50368977(CHEMBL4163069 | US11124537, TABLE 3.31.1)
Affinity DataEC50: >2.50E+3nMAssay Description:Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)