Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 6GJ6
TargetGTPase KRas (G12D) and Son of Sevenless Homolog 1 (SOS)(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50549223(CHEMBL4796065 | US12281099, Example I-003)
Affinity DataIC50: 6.90E+3nMAssay Description:Measurement of various protein-protein interactions was performed using the Alpha Screen technology developed by Perkin Elmer. Recombinant RAS protei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50549223(CHEMBL4796065 | US12281099, Example I-003)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to GCP-KRAS G12D (unknown origin) by isothermal titration calorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGTPase KRas(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50549223(CHEMBL4796065 | US12281099, Example I-003)
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of C-terminal Avi-tagged biotinylated KRas G12D mutant (1 to 169 residues) (unknown origin) expressed in Escherichia coli assessed as redu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGTPase KRas [G12D]/Son of sevenless homolog 1 [564-1049](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50549223(CHEMBL4796065 | US12281099, Example I-003)
Affinity DataIC50: 3.37E+4nMAssay Description:The following binding partners have been used in this assay. Biotinylated KRAS G12D protein corresponding to KRAS (amino acids 1-169, with the follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2025
Entry Details
US Patent
PDB3D3D Structure (crystal)