Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 6LRC
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human Cyclic GMP-AMP synthase (2 to 522 residues) expressed in Sf9 cells by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataKd:  200nMAssay Description:Binding affinity to human cGas assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclic GMP-AMP synthase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50250108(CHEMBL4096573)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human cGas in presence of ATP by mass spectrometry analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)