Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Displacement of tritiated 2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from human N-(HN)6-GST-TCS-RORC LBD (258 ...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inverse agonist activity at mouse RORC ligand binding domain incubated for 30 mins by scintillation proximity binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Displacement of tritiated 2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from mouse HN-AVI-GST-TCS-RORC (256 to 51...More data for this Ligand-Target Pair
Affinity DataIC50: 182nMAssay Description:Inverse agonist activity at human RORC ligand binding domain incubated for 30 mins by scintillation proximity binding assayMore data for this Ligand-Target Pair
