Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) for PDB: 6UWU
TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 84nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  84nMAssay Description:Binding affinity to recombinant BRD4 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 84nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 280nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible CIG5 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 310nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible IL-6 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  718nMAssay Description:Binding affinity to recombinant BRD4 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 720nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 886nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 886nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.12E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.12E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 8.22E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)