Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 6XFP
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 7nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [V600E](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 7nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 9nMAssay Description:Inhibition of B-RAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 56nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2016
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf [409-765](Human)
Hanmi Pharm.

US Patent
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 56nMAssay Description:The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM185591(US9156852, 116 | USRE47451, Example 116 | US121394...)
Affinity DataIC50: 116nMAssay Description:Inhibition of B-RAF (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)