BindingDB PrimarySearch

Report error Found 10 Enz. Inhib. hit(s) for PDB: 6YTD

Dual specificity protein kinase CLK4(Mouse)
German University In Cairo

Curated by ChEMBL

Chemical structure of BindingDB Monomer ID 50026622

IC50: 15nMAssay Description:Inhibition of GST-tagged mouse CLK4 expressed in Escherichia coli using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH as substrate after 10 mins in presence o...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
9/26/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK4(Mouse)
German University In Cairo

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 15nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Clk4 expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide a...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
6/20/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK4(Mouse)
German University In Cairo

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 15nMAssay Description:Inhibition of GST-tagged recombinant mouse CLK4 expressed in Escherichia coli using RSPSYGRSRSRSRSRSRSRSRSNSRSRSY as substrate in presence of [gamma-...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
6/18/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 17nMAssay Description:Inhibition of recombinant human CLK1 expressed in insect cells using ERMRPRKRQGSVRRRV peptide as substrate after 40 mins in presence of [gamma-33P]-A...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
9/16/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 20nMAssay Description:Inhibition of Clk1 (unknown origin) using synthetic peptide of SF2/ASF RS domain by [gamma-32P]ATP binding assayMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

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Date in BDB:
12/22/2024
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Mouse)
German University In Cairo

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 20nMAssay Description:Inhibition of mouse glutathione S-transferase-tagged Clk1 expressed in Escherichia coli DH5alpha using NH2-RSPSYGRSRSRSRSRSRSRSRSNSRSRSY-OH peptide a...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Date in BDB:
6/20/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 20nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
6/21/2023
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 26nMAssay Description:Inhibition of CLK1 (unknown origin) preincubated with enzyme for 10 mins followed by substrate and ATP addition measured after 60 mins by ADP-Glo rea...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
10/12/2025
Entry Details
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 49nMAssay Description:Inhibition of human C-terminus CLK1 (148 to 484 residues) expressed in Escherichia coli BL21(DE3) using AFRREWSPGKEAKK as substrate preincubated for ...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
9/26/2019
Entry Details Article
PubMed PDB

3D Structure (crystal)

Dual specificity protein kinase CLK1(Human)
Sichuan University and Collaborative Innovation Center For Biotherapy

Curated by ChEMBL

BDBM50026622(CHEMBL408982)

IC50: 170nMAssay Description:Inhibition of recombinant Clk1 (unknown origin) using GRSRSRSRSR peptide substrateMore data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Date in BDB:
3/7/2016
Entry Details Article
PubMed PDB

3D Structure (crystal)

Filter my 10 hits

Targets 2▿
- Dual specificity protein kinase CLK1 7
- Dual specificity protein kinase CLK4 3
Publications 8▿
- J Med Chem 60: 5377-5391 (2017) 2
- Eur J Med Chem 238: (2022) 2
- J Med Chem 60: 6337-6352 (2017) 1
- ACS Med Chem Lett 5: 963-7 (2014) 1
- Bioorg Med Chem 70: (2022) 1
- Bioorg Med Chem 62: (2022) 1
- Eur J Med Chem 250: (2023) 1
- J Med Chem 67: 12571-12600 1
Institutions 7▿
- German University In Cairo 4
- Shenyang Pharmaceutical University 1
- West China Hospital of Sichuan University 1
- Sichuan University and Collaborative Innovation Center For Biotherapy 1
- Saarland University 1
- Western University of Health Sciences 1
- University of Canterbury 1
Affinity: 15 to 1.7E+2 nM▿
- IC50 10
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1