Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 7AWE
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.40nMAssay Description:Inhibition of 20S immunoproteasome beta-5i subunit in human PBMC using Ac-ANW-luciferin substrate preincubated for 2 hrs followed by substrate additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Suc-LLVY-AMC as substrate preincubated for 2 hrs followed by substrate addition and me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-8(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 8nMAssay Description:Inhibition of human LMP7 beta -5i subunit using Ac-ANW-AMC as substrate preincubated with compound for 30 mins followed by substrate addition and mea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-10(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-2i subunit using Ac-RLR-AMC as substrate preincubated for 2 hrs followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-1i subunit using (Ac-PAL)2R110 as substrate preincubated for 2 hrs followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProteasome subunit beta type-9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50601643(CHEMBL5184466)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human LMP2 beta-1i subunit using Ac-PAL-AMC as substrate preincubated with compound for 30 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)