Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 7EG0
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 50nMAssay Description:Inhibition of hydrolysis of c-AMP phosphodiesterase in human plateletsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 54nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 80nMAssay Description:In vitro inhibition of cyclic AMP phosphodiesterase from human platelets.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 80nMAssay Description:Inhibition of platelet cAMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 82nMAssay Description:Inhibition of human blood platelet c-AMP phosphodiesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000334(Agrylin | 6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]q...)
Affinity DataIC50: 1.05E+3nMAssay Description:Inhibition of human platelet c-AMP phosphodiesterase PDE 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)