Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) for PDB: 7EJ8
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  0.617nMAssay Description:Alpha-2A adrenergic receptor agonistic potency as inhibition of forskolin-stimulated synthesis of cyclic adenosine monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2018
Entry Details
PDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to alpha2 adrenoceptor in human cortical membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for Alpha-2 adrenergic receptor of CHO-C10 membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2018
Entry Details
PDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards Alpha-2 adrenergic receptor of HT-29 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2018
Entry Details
PDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  2.70nMAssay Description:Displacement of rauwolscine from human Alpha-2A adrenergic receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of [3H]p-aminoclonidine (PAC) binding to alpha-2 adrenergic receptor of purified human platelet plasma membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataIC50: 3.60nMAssay Description:Binding affinity against Alpha-2 adrenergic receptor is the ability to inhibit the specific [3H]clonidine binding (0.4 nM) to rat isolated brain memb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  4.10nMAssay Description:Effective concentration at Alpha-2A adrenergic receptor from CHO-C10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  30nMAssay Description:Binding affinity towards alpha-2 adrenergic receptor in rat using [3H]rauwolscine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A adrenergic receptor(Mouse)
Roche Bioscience

Curated by PDSP Ki Database
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  43.6nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  214nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A adrenergic receptor(Pig)
University of Michigan

Curated by PDSP Ki Database
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataKi:  479nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  1.14E+4nMAssay Description:Agonist activity at alpha2 adrenoceptor in human cortical membrane after 2 hrs by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-2A/Alpha-2B/Alpha-2C adrenergic receptor(Human)
University of Dublin

Curated by ChEMBL
LigandPNGBDBM34572(UK 14,304 | SMR000058355 | CHEMBL844 | cid_2435 | ...)
Affinity DataEC50:  1.14E+4nMAssay Description:Agonist activity at human brain adrenergic alpha2 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)