Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 7REC
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]HOCPCA from native CaMK2alpha in rat brain cortical membrane homogenates measured after 1 hr by TopCount scintillation counting m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cortical membrane homogenates measured after 1 hr by TopCount scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataKi:  800nMAssay Description:Displacement of [3H]HOCPCA from recombinant rat CaMK2alpha expressed in HEK293T cells measured after 1 hr by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataKi:  900nMAssay Description:Displacement of [3H]NCS-382 from CaMK2alpha in rat brain cerebral cortex membrane homogenates assessed as inhibition constant measured after 60 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50228744(CHEBI:59612 | 5-Hydroxy-Diclofenac)
Affinity DataIC50: 1.81E+3nMAssay Description:Binding affinity to recombinant human CaMK2alpha 6x hub domain (345 to 475 residues) Trp403 residue assessed as inhibition of intrinsic tryptophan fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)