Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 7Y5T
LigandChemical structure of BindingDB Monomer ID 28986BDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: 5nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 28986BDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: 14nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandChemical structure of BindingDB Monomer ID 28986BDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: 15nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Centre Hospitalier Universitaire Vaudois (Chuv)

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 28986BDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataIC50: 65nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP assessed as reduction in amyloid beta levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)