BindingDB PrimarySearch

Report error Found 29 Enz. Inhib. hit(s) for PDB: 7Y7Y

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 10nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair

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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 1.90E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 1.95E+3nMAssay Description:H-bonding interaction between amino acid residue (Asn-137) of Sodium- and chloride-dependent GABA transporter 1TM3 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.56E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.56E+3nMAssay Description:H-bonding interaction between amino acid residue (Thr-89) of Sodium- and chloride-dependent GABA transporter 1TM2 and compoundMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.63E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.74E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.78E+3nMAssay Description:H-bonding interaction between amino acid residue (Tyr-140) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 2.86E+3nMAssay Description:H-bonding interaction between amino acid residue (Ser-133) of Sodium- and chloride-dependent GABA transporter 1TM3 and compound was determinedMore data for this Ligand-Target Pair

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Date in BDB:
12/3/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 5.90E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 5.90E+3nMAssay Description:Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
4/13/2014
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 5.96E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 6.46E+3nMAssay Description:Inhibition of mouse GAT1 assessed as reduction in GABA uptakeMore data for this Ligand-Target Pair

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Date in BDB:
6/26/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 8.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2013
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 8.00E+3nMAssay Description:Inhibition of human GAT1 expressed in COS cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
2/25/2021
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 8.00E+3nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair

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Date in BDB:
11/10/2009
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 8.51E+3nMAssay Description:Inhibition of mouse GAT1 expressed in HEK cells assessed as inhibition of [3H]-GABA uptake after 25 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
9/1/2020
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

IC50: 1.33E+4nMAssay Description:Inhibition of mouse GAT1 expressed in HEK293 cells assessed as [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA/unlabeled GABA addition ...More data for this Ligand-Target Pair

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Date in BDB:
7/9/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Rat)
University of Urbino

Curated by ChEMBL

BDBM50003624(Nipecotic | Piperidine-3-carboxylic acid(nipecotic...)

Ki: 5.82E+4nMAssay Description:Displacement of NO 711 from mouse GAT1 expressed in HEK293 cell membranes after 40 mins by LC-ESI-MS-MS-based MS binding assayMore data for this Ligand-Target Pair

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Date in BDB:
7/9/2017
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Human)
Synaptic Pharmaceutical

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 8.15E+4nMAssay Description:Inhibition of GAT1 transport activityMore data for this Ligand-Target Pair

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Date in BDB:
12/5/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 4.56E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair

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Date in BDB:
12/13/2012
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 4.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2013
Entry Details Article
PubMed PDB

3D Structure (crystal)

Sodium- and chloride-dependent GABA transporter 1(Mouse)
Ludwig Maximilians University At Munich

Curated by ChEMBL

BDBM50020883(CHEMBL77575 | (R)-Piperidine-3-carboxylic acid | N...)

IC50: 4.07E+7nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair

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Date in BDB:
9/24/2013
Entry Details Article
PubMed PDB

3D Structure (crystal)

Filter my 29 hits

Targets 1▿
- Sodium- and chloride-dependent GABA transporter 1 29
Publications 12▿
- J Med Chem 47: 5620-9 (2004) 14
- J Med Chem 56: 2160-4 (2013) 2
- Bioorg Med Chem 24: 2072-96 (2016) 2
- J Med Chem 37: 2334-42 (1994) 2
- Bioorg Med Chem 27: 1232-1245 (2019) 2
- Bioorg Med Chem 21: 4938-50 (2013) 1
- J Med Chem 56: 1323-40 (2013) 1
- Bioorg Med Chem Lett 17: 3769-73 (2007) 1
- Bioorg Med Chem 21: 3363-78 (2013) 1
- J Med Chem 48: 6887-96 (2005) 1
- Bioorg Med Chem Lett 16: 225-7 (2005) 1
- J Med Chem 61: 6211-6235 (2018) 1
Institutions 11▿
- Budapest University of Technology and Economics 14
- Ludwig-Maximilians-University Munich 2
- Synaptic Pharmaceutical 2
- University of Copenhagen 2
- Ludwig-Maximilians-Universit£T M£Nchen 2
- Ludwig-Maximilians-University M£Nchen 2
- Hokkaido University 1
- Fudan University 1
- University of Urbino 1
- Ludwig Maximilians University At Munich 1
- Zhengzhou University 1
Affinity: 10 to 4.1E+7 nM▿
- Ki 1
- IC50 28
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 2