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Report error Found 10 Enz. Inhib. hit(s) for PDB: 8BM2
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2 (unknown origin) by Lanthascreen kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of recombinant human JAK2 assessed as inhibition of substrate phosphorylation measured every 5 mins for 30 mins by LANCE Ultra kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human JAK2 kinase domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant human JAK2 kinase domain (840 to 1132 residues) assessed as dissociation constant by fluorescence polarization measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 55nMAssay Description:Inhibition of JAK2 V617F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 68nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 155nMAssay Description:Inhibition of JAK2-mediated erythropoietin-induced STAT5 phosphorylation in human TF-1 cells pretreated for 60 mins followed by erythropoietin additi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of IL-3 stimulated wild type JAK2-mediated signalling in mouse BaF3 cells preincubated with compound for 5 hrs followed by IL-3 stimulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase JAK2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50591313(Gandotinib | Ly-2784544 | Ly2784544 | LY-2784544 |...)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of wild type JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)