Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 8CK8
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618767BDBM50618767(CHEMBL5422094)
Affinity DataKd:  1.25E+5nMAssay Description:Binding affinity to human recombinant HIF-2alpha (240 to 350 residues) assessed as as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618767BDBM50618767(CHEMBL5422094)
Affinity DataIC50: 1.66E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells transfected with HRE-luc2P assessed as decrease in luminescence incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetEndothelial PAS domain-containing protein 1(Human)
Merck Healthcare

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50618767BDBM50618767(CHEMBL5422094)
Affinity DataIC50: 2.99E+5nMAssay Description:Inhibition of HIF-2alpha transcriptional activity in human 786-0 cells assessed as decrease in VEGF production incubated for 48 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMedPDB3D3D Structure (crystal)