Compile Data Set for Download or QSAR
Report error Found 5 Enz. Inhib. hit(s) for PDB: 8KCT
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human gamma-secretase by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of human gamma-secretaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 6.20nMAssay Description:Inhibition of gamma secretase isolated from human HeLa cell derived P2 membrane assessed as reduction in amyloid beta (1 to 40 residues) using recomb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPresenilin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50458159(Nirogacestat | PF 03084014 | PF 3084014 | PF-03084...)
Affinity DataIC50: 19nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in notch signaling by fetal thymus organ culture assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)