Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 8QNH
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataKd:  3nMAssay Description:Binding affinity to avidin-biotinylated Cbl-b at (36 to 427 residues) (unknown origin) assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataIC50: 5nMAssay Description:Inhibition of Cbl-b (unknown origin) ubiquitination by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant Cbl-b (unknown origin) ubiquitination incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataKd:  8nMAssay Description:Binding affinity to CBl-b (unknown origin) assessed as dissociation constant by Surface plasmon resonanceMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataIC50: 9nMAssay Description:Inhibition of Cbl-b (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634588(CHEMBL5421689)
Affinity DataIC50: 9nMAssay Description:Displacement of FAM-labeled probe from recombinant biotinylated Cbl-b (unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)