Compile Data Set for Download or QSAR
Report error Found 4 Enz. Inhib. hit(s) for PDB: 8QNI
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 15nMAssay Description:Displacement of FAM-labeled probe from recombinant biotinylated Cbl-b (unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells by TR-FRET...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataEC50:  410nMAssay Description:Inhibition of Cbl-b in cryo-preserved human CD3-positive T cells assessed as increase in IL-2 production preincubated for 1 hr followed by alpha-CD3 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of recombinant Cbl-b (unknown origin) mediated ZAP70 ubiquitination incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50634563(CHEMBL5434221)
Affinity DataIC50: 5.05E+4nMAssay Description:Inhibition of recombinant Cbl-b (unknown origin) ubiquitination incubated for 60 mins in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)