Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) for PDB: 8QTK
TargetE3 ubiquitin-protein ligase CBL-B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataIC50: 30nMAssay Description:Inhibition of biotinylated recombinant Cbl-b (36 to 427 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells using a FAM-lab...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataIC50: 30nMAssay Description:Inhibition of biotinylated recombinant Cbl-b (36 to 427 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) measured for 1 hr by TR-FRE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL(Homo sapiens)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataIC50: 50nMAssay Description:Inhibition of cCbl (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataIC50: 63nMAssay Description:Inhibition of biotinylated recombinant Cbl-b (36 to 427 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells assessed as dec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataIC50: 84nMAssay Description:Inhibition of biotinylated recombinant Cbl-b (36 to 427 residues)(unknown origin) expressed in Escherichia coli BL21(DE3) Tuner cells assessed as dec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase CBL-B(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50642865(CHEMBL5565433)
Affinity DataEC50:  610nMAssay Description:Inhibition of Cbl-b in CD3/CD28-stimulated human T cells assessed as increase in PLC-gamma1 phosphorylation at Tyr783 preincubated for 15 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)