Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) for PDB: 8T7Q
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 595804BDBM595804(US11629145, Compound 8 | US11591336, Compound 6)
Affinity DataIC50: 38nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 595804BDBM595804(US11629145, Compound 8 | US11591336, Compound 6)
Affinity DataIC50: 1.00E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/27/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 595804BDBM595804(US11629145, Compound 8 | US11591336, Compound 6)
Affinity DataIC50: 1.00E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2023
Entry Details
US Patent
PDB3D3D Structure (crystal)