Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) for PDB: 8THL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  5.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataIC50: 17nMAssay Description:Binding affinity against Alpha adrenergic receptor using [3H]dihydroergocryptine radioligand in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  200nMAssay Description:Compound was evaluated for inhibition of [3H]prazosin binding to Alpha-1 adrenergic receptor in rat forebrain homogenate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataEC50:  400nMAssay Description:Agonistic potency at alpha-1 adrenergic receptor for the amine-induced increase of phosphatidylinositol breakdown in synaptoneurosomes from guinea pi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  590nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2011
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetAlpha-1A adrenergic receptor(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  2.00E+3nMAssay Description:Binding affinity against alpha-1 adrenergic receptor in guinea pig cerebral cortical membranes by displacement of [3H]- WB-4101More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50029050(4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2...)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H]WB-4101 from adrenergic alpha 1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)