TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of HPK1 (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 0.320nMAssay Description:Inhibition of HPK1 (unknown origin) using His-tagged SLP-76 as substrate preincubated for 30 mins followed by substrate and ATP addition and measured...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of N-terminal nanoluc-fused HPK1 (unknown origin) expressed in HEK293T cells preincubated for 2 hrs in presence of cell permeable fluoresc...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of HPK1 in human PBMC cells assessed as inhibition of SLP76 phosphorylation pretreated for 1 hr followed by anti-CD3/CD28 addition and mea...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylation pretreated for 1 hr followed by anti-CD3/CD28 addition and m...More data for this Ligand-Target Pair
